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5 Essential Probiotics for Optimal Gut Health

Discover the science behind 2024’s must-have probiotics

  • Written by: Brilliant Staff
  • Fact Checked by: SaVanna Shoemaker, MS, RDN, LD
provibiotics supplements
In today's health-conscious world, probiotics offer a comprehensive and science-backed solution to promoting proper and consistent digestion. 

These live microorganisms are recognized for their ability to restore balance in the gut and alleviate common and uncomfortable digestive issues. They work synergistically to enhance nutrient absorption and strengthen the immune system.

As more people seek naturally sourced remedies for their health, probiotics have emerged as a powerful solution for achieving optimal wellness and vitality.

Benefits of Probiotics

  • Supports Digestive Health

  • Strengthens Immune System Response

  • Enhances Nutrient Absorption

  • Promotes Cognitive, Skin, & Oral Health

The gut microbiome plays a crucial role in maintaining gut health, helping break down hard-to-digest foods, and inhibiting the adherence of bacteria to the intestinal walls, which can go a long way to maintaining a healthy immune response.

There are several factors that contribute to probiotics’ beneficial effects. One is a diverse range of probiotic strains, which play a key role in promoting a healthy gut. 

Different probiotic strains have different mechanisms-of-action. Research suggests that probiotics formulated with a diverse range of strains may have a greater impact on gut health.

When shopping for probiotics, look for formulations that contain 10 or more strains to ensure you're giving your gut the best support possible.
human intestins
Another important component of quality probiotics is prebiotics, which are essentially “food” for probiotics. 

Inulin, for example, is a common prebiotic fiber; but it’s one that our bodies cannot break down without the help of probiotics. Beneficial gut bacteria help ferment inulin, working together to support a balanced microbiome.

Just as you have your favorite foods, the bacteria in your gut require certain foods to thrive. In order to function efficiently, specific nutrients are needed to keep your gut health in exceptional shape.
probiotic foods
  • As more people seek naturally sourced remedies for their health, probiotics have emerged as a powerful solution for achieving optimal wellness and vitality.
  • As more people seek naturally sourced remedies for their health, probiotics have emerged as a powerful solution for achieving optimal wellness and vitality.
To supplement a healthy diet, you can easily incorporate gut-healthy, prebiotic-rich foods into your daily routine by choosing a high-quality probiotic that already includes beneficial prebiotics.

So, which strains should you look for in your probiotic supplement? Our advice? Diversify! 

Here's a short list of key probiotic strains we love — with a prebiotic thrown in!

Step 1

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Step 2

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Step 3

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Key Probiotic Strains

L. rhamnosus

Lactobacillus rhamnosus belongs to the Lactobacillus genus of probiotic bacteria. This particular strain has been studied for its potential to promote digestive health and improve immune function, along with supporting skin health and weight management.

B. lactis

Bifidobacterium lactis has not only been shown to promote a balanced gut microbiome by aiding the absorption of various vitamins and minerals but has also been associated with having a positive impact on respiratory health.

B. lactis may improve the function of immune cells that play a vital role in defending the body against environmental threats.

In addition, some studies suggest that B. lactis may aid individuals with bowel concerns by reducing symptoms.

L. salivarius

Lactobacillus salivarius supports oral health by inhibiting the growth of bacteria in the mouth. This can lead to healthy gums, strong teeth, and improvements in the presence of plaque and probing pocket depths.

L. salivarius also has the ability to produce a small amount of hydrogen peroxide (H2O2) and may help reduce the presence of bad breath.

In addition to its oral health benefits, L. salivarius has positive effects on gastrointestinal health. Some research suggests that L. salivarius may help minimize some symptoms of common gastrointestinal discomfort.

B. longum

Bifidobacterium longum promotes the activity of immune cells, such as T cells, which defend the body. It has also shown promise in promoting mental well-being by reducing cortisol output as it relates to common stressors.
Prebiotic Fructo-oligosaccharides (FOS)
Prebiotics are like fertilizer for the good bacteria in your gut. They provide the necessary nourishment to probiotics, ensuring they flourish and maintain a healthy balance. 

Plant-based FOS are short-chain, soluble fibers that go beyond gut health, helping support your immune system, boost nutrient absorption, and promote a radiant complexion. They’re also a solid source of fiber.

Watch Out For

Low CFU Count

Colony Forming Units, commonly referred to as CFUs, play a significant role in understanding the effectiveness of probiotics. CFU indicates the precise quantity of beneficial bacteria present in each dosage, and a higher number corresponds to greater potential health benefits. We recommend a minimum of 45 billion CFUs for optimal results.

Limited Number of Strains

When it comes to maintaining general health and supporting the immune system, we recommend seeking a probiotic supplement that incorporates a minimum of 10 distinct probiotic strains. This diverse range of probiotic strains ensures a broader spectrum of benefits, as each strain contributes its unique properties and capabilities to promote a balanced and resilient gut microbiome.

Powders or Gummies

Typically, opting for probiotics in capsule form is more advantageous compared to powders or gummies. Capsules provide superior protection against gastric acids that have the potential to eliminate bacteria before they reach the intestines. This becomes especially crucial when your probiotics include strains that are susceptible to stomach acid destruction.

The Brilliant Process

How We Choose Products

Like you, we’re picky about products — and serious about quality. 

Whether we’re featuring an award-winning product from one of our five beauty and wellness brands — or somebody else’s — a Brilliant recommendation doesn’t see the light of day until it has been medically reviewed by our Fact Checkers for accuracy and has fulfilled our Brilliant Criteria. 

At Brilliant, although we often feature products we sell, we’re not afraid to highlight and celebrate other brands who are doing things right.

Brilliant Criteria

We take great care in handpicking high-quality products to feature on Brilliant. Here’s how we choose them:
  • High-Quality Ingredients: We dig deep into the latest research and look for products that contain comprehensive ingredients for optimal impact.
  • Pure, Holistic Formulas: We prioritize products that contain clean, wholesome ingredients. A product should only contain what it needs and nothing else—period.
  • Brand Credibility: Each product on our list is produced by a company with trusted credibility. We've also verified that each brand adheres to labeling requirements set forth under current Good Manufacturing Practices (cGMP).
  • Value: We evaluate products based on industry averages and price per serving or application. We also consider quantity and return policy.

Why Trust Us?

As veteran leaders in the wellness space with an award-winning brand portfolio of 100+ health and beauty products, we are committed to honesty and transparency, providing thoughtful insights into the benefits and limitations of the information and products we evaluate — including our own. Every Brilliant Buying Guide is thoroughly vetted for medical accuracy by our Fact Checkers prior to publication. 

With our discerning selection process, you can feel confident that the products we recommend meet the highest benchmarks of quality, transparency, and efficacy. If we wouldn’t use a product ourselves, it’s not Brilliant. 
Now that you know what to look for and what to avoid in a gut health supplement, it’s time to shop! 

Check out our Brilliant recommendations below, including our own 1MD Nutrition® Complete Probiotics Platinum® and Live Conscious® Pro-45®.
bw-bg-probiotics-comparison-chart-e

2024’s Essential Probiotics for Optimal Gut Health

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What is lorum ipsum?

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What is lorum ipsum?

Tellus facilisis donec blandit massa nibh nunc. Ipsum maecenas lobortis turpis amet volutpat sed. Sit lectus velit ac rutrum. Amet suspendisse est suspendisse dignissim euismod amet lorem amet cursus. Massa turpis vitae porttitor et.

What is lorum ipsum?

Tellus facilisis donec blandit massa nibh nunc. Ipsum maecenas lobortis turpis amet volutpat sed. Sit lectus velit ac rutrum. Amet suspendisse est suspendisse dignissim euismod amet lorem amet cursus. Massa turpis vitae porttitor et.

What We Like:

    • Scientifically formulated
    • 50+ billion CFUs
    • Formulated with prebiotics 
    • Over 10 unique probiotic strains
    • Soy, gluten, dairy free
    • No refrigeration necessary
    • 1 capsule per day
    • Good manufacturing practices 
    • 90-day return policy

Room To Improve:

    • Sold exclusively online

Final Thoughts

Endorsed by Gastroenterologist Dr. David Kahana, 1MD Nutrition’s Complete Probiotics Platinum® is scientifically formulated with 51 billion powerful CFUs, 11 robust strains, and clinically backed NutraFlora® prebiotic in each delayed-release 1-capsule serving, all without unnecessary fillers. 

Our award-winning probiotic formula is also vegan, non-GMO, and manufactured in a GMP-certified facility to ensure purity and consistency. 

If for any reason you are not satisfied with Complete Probiotics Platinum®, we offer a 100% satisfaction, 90-day money-back guarantee.

Product Specs

  • 30 capsules per bottle (30 servings) 
  • 51 Billion CFU probiotic blend (308 mg)
  • NutraFlora® prebiotic FOS (50 mg)
  • Dairy Free, Shellfish Free, Peanut Free, Gluten Free, Soy Free, Preservative Free, Non-GMO
  • Price: $$

What We Like:

    • Formulated with prebiotics 
    • Over 10 unique probiotic strains
    • Soy, gluten, dairy free
    • No refrigeration necessary
    • 1 capsule per day
    • Good manufacturing practices 
    • 365-day return policy

Room To Improve:

    • Formula potency

Final Thoughts

Live Conscious® Pro-45 is formulated with 45 billion CFUs and 11 probiotic strains and also features NutraFlora® prebiotic to help promote the vitality and growth of good gut flora. 

Pro-45 is also non-GMO, dairy-free, and manufactured in a GMP-certified facility. 



If, for any reason, you are not satisfied, we offer a 365-day return policy. It’s equally important to consider the scientific formulation of ingredients. Scientifically formulated ingredients can ensure the efficacy and potency of the probiotics, maximizing their potential health benefits.

Product Specs

  • 30 capsules per bottle (30 servings) 
  • 45 Billion CFU probiotic blend (308 mg)
  • NutraFlora® prebiotic FOS (50 mg)
  • Dairy Free, Shellfish Free, Peanut Free, Gluten Free, Soy Free, Preservative Free, Non-GMO
  • Price: $$

What We Like:

    •  Scientifically formulated
    • 50+ billion CFUs
    • Formulated with prebiotics 
    • Over 10 unique probiotic strains
    • Soy, gluten, dairy free
    • No refrigeration necessary
    • 1 capsule per day

Room To Improve:

    • 60-day return policy

Final Thoughts

Garden of Life's Dr. Formulated Probiotics Immune capsules contain 50 Billion CFU of diverse strains per serving, while also providing a prebiotic blend to promote the growth of good bacteria — something we're definitely on board with! 

Their formula contains a blend of postbiotics and vitamin D3, plus zinc for additional immune support.

Garden of Life is a carbon-neutral company known for their commitment to high standards for sustainable and clean practices, so like ours, you can count on non-GMO probiotics but with the USDA Organic certification. 

When it comes to supplements, consistency is key for optimal absorption, cumulative benefits, and long-term effects on overall health and well-being, which is why we believe supplements should strive for a 90-day or more return policy. Garden of Life offers a 60-day return policy.

Product Specs

  • 30 capsules per bottle (30 servings) 
  • 50 Billion CFU probiotic blend (170 mg)
  • PreforPro® prebiotic blend (110 mg)
  • Upcycled postbiotic blend (50 mg)
  • Vitamin D (20 mcg)
  • Zinc (11 mcg)
  • Dairy Free, Gluten Free, Soy Free, Preservative Free, Non-GMO
  • Price: $$

What We Like:

    • Scientifically formulated
    • 50+ billion CFUs
    • Formulated with prebiotics 
    • Over 10 unique probiotic strains
    • Soy, gluten, dairy free
    • No refrigeration necessary

Room To Improve:

    • Only 30-day return policy
    • Price Point

Final Thoughts

If you’re looking for a new kind of probiotic and prebiotic blend, Seed's DS-01® Daily Synbiotic is worth your consideration. 

With a higher potency per serving than our previous recommendations, two capsules daily of Seed's DS-01® Daily Synbiotic contains 53.6 Billion AFU from 24 unique strains. An alternative to CFU, Active Fluorescent Units (AFU), is a more accurate form of testing that utilizes flow cytometry for precise enumeration of viable cells. And like our probiotics, Seed's DS-01® Daily Synbiotic is non-GMO and free of soy, dairy, and gluten.

At the moment, DS-01® Daily Synbiotic is only available for purchase via subscription and comes with a 30-day return policy.

Product Specs

  • 60 capsules per bottle (30 servings) 
  • 53.6 Billion AFU probiotic blend 
  • Microbiota-Accessible Polyphenolic Precursors™️ (Indian Pomegranate) (400 mg)
  • Dairy Free, Shellfish Free, Gluten Free, Soy Free, Preservative Free
  • Price: $$$

What We Like:

    • Scientifically formulated
    • 50+ billion CFUs
    • Over 10 unique probiotic strains
    • Soy, gluten, dairy free
    • No refrigeration necessary
    • 1 capsule per day
    • 60-day return policy

Room To Improve:

    • No prebiotics
    • 60-day return policy

Final Thoughts

With a potent blend of 50 billion CFUs and 12 diverse strains, this powerhouse probiotic has you covered. 

Each capsule delivers guaranteed potency through expiration, ensuring maximum effectiveness. Like our own probiotics, along with the other recommendations on this list, refrigeration is not necessary — and just one capsule a day does all of the work! 

While the number of CFUs is suitable for those requiring sufficient gut support, prebiotics were not added to this particular blend.

Product Specs

  • 30 capsules per bottle (30 servings) 
  • 50 Billion CFU probiotic blend (152 mg)
  • Dairy Free, Gluten Free, Soy Free, Non-GMO
  • Price: $

Frequently Asked Questions

What are the benefits of a multi-strain probiotic supplement?

Probiotics have been shown to promote a healthy gut microbiome, which aids in the breakdown and absorption of specific nutrients and medications, as well as producing essential nutrients. 

Probiotics also support the immune system by identifying and eliminating unwanted microbes. In addition, they may have positive effects on mood, mental clarity, fatigue levels, immune response, metabolism, blood sugar, and fat storage.

Is it normal to have some gas and bloating when taking probiotics?

Although probiotics are generally safe, it’s possible to experience mild gastrointestinal symptoms when initially starting probiotic supplements or increasing the consumption of probiotic-rich foods. 

Typically, these symptoms are temporary and should subside within a few days as your body adjusts to the new routine.

Does our microbiome change as we age?

Our gut microbiome is influenced by various factors, including diet, lifestyle, medication use, stress, and age. As we age, changes occur in the gut microbiome that impact digestion and immunity, making us more vulnerable. 

Specifically, the composition and diversity of gut bacteria can be altered. A decrease in beneficial bacteria disrupts the delicate balance between bacteria. Maintaining a healthy balance is crucial for optimizing healthy immune responses.

Citations

  1. Ahmed, Waqas, and Summer Rashid. Critical Reviews in Food Science and Nutrition vol. 59,1 (2019): 1-13. doi:10.1080/10408398.2017.1355775
  2. Badal, Varsha D et al. Nutrients vol. 12,12 3759. 7 Dec. 2020, doi:10.3390/nu12123759
  3. Capurso, Lucio. Journal of Clinical Gastroenterology vol. 53 Suppl 1 (2019): S1-S41. doi:10.1097/MCG.0000000000001170
  4. Chapman, C M C et al. Anaerobe vol. 18,4 (2012): 405-13. doi:10.1016/j.anaerobe.2012.05.004
  5. Davani-Davari, Dorna et al. Foods (Basel, Switzerland) vol. 8,3 92. 9 Mar. 2019, doi:10.3390/foods8030092
  6. Dore, Maria Pina et al. Nutrients vol. 11,12 2913. 2 Dec. 2019, doi:10.3390/nu11122913
  7. Gavzy, Samuel J et al. Gut Microbes vol. 15,2 (2023): 2291164. doi:10.1080/19490976.2023.2291164
  8. Iwamoto, Tomoyuki et al. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics vol. 110,2 (2010): 201-8. doi:10.1016/j.tripleo.2010.03.032
  9. Kim, Jung-Hwan et al. The Journal of Allergy and Clinical Immunology vol. 137,2 (2016): 507-516.e8. doi:10.1016/j.jaci.2015.08.016
  10. Maynard, Claire, and David Weinkove. Sub-cellular Biochemistry vol. 90 (2018): 351-371. doi:10.1007/978-981-13-2835-0_12
  11. Meng, Huicui et al. Molecular Nutrition & Food Research vol. 60,5 (2016): 1161-71. doi:10.1002/mnfr.201500665
  12. Neville, B A, and P W O'Toole. Future microbiology vol. 5,5 (2010): 759-74. doi:10.2217/fmb.10.35
  13. Nishihara, Tetsuyo et al. BMC Oral Health vol. 14 110. 2 Sep. 2014, doi:10.1186/1472-6831-14-110
  14. Pengrattanachot, Nattavadee et al. Food & Function vol. 13,11 5925-5945. 6 Jun. 2022, doi:10.1039/d1fo04428a
  15. Qin, Yu-Qing et al. Food & Function vol. 14,7 2948-2968. 3 Apr. 2023, doi:10.1039/d2fo01096h
  16. Rasinkangas, Pia et al. The American Journal of Clinical Nutrition vol. 116,6 (2022): 1580-1594. doi:10.1093/ajcn/nqac264
  17. Sabater-Molina, M et al. Journal of Physiology and Biochemistry vol. 65,3 (2009): 315-28. doi:10.1007/BF03180584
  18. Sanchez, Marina et al. The British Journal of Nutrition vol. 111,8 (2014): 1507-19. doi:10.1017/S0007114513003875
  19. Shimauchi, Hidetoshi et al. Journal of Clinical Periodontology vol. 35,10 (2008): 897-905. doi:10.1111/j.1600-051X.2008.01306.x
  20. Singh, Sudhir P et al. Applied Biochemistry and Biotechnology vol. 183,2 (2017): 613-635. doi:10.1007/s12010-017-2605-2
  21. Wang, Huiying et al. The American Journal of Gastroenterology vol. 114,7 (2019): 1152-1162. doi:10.14309/ajg.0000000000000203
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