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The Most Effective SAM-e Supplements You Can Buy

Your guide to the remarkable benefits of SAM-e for mood, joint, and overall health.

  • Written by: Brilliant Staff
  • Fact Checked by: SaVanna Shoemaker, MS, RDN, LD
Benefits
Key Ingredients
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While it might sound new, SAM-e has been a popular supplement in Europe for many years, and it’s gaining traction and growing in popularity in the United States.

SAM-e, or S-adenosylmethionine, is a compound naturally made by our bodies and is involved in many biochemical reactions. 

Unfortunately, as we age and deal with everyday stress, our SAM-e levels decline. That's where SAM-e supplementation comes to the rescue!

Benefits

  • Boosts Mood & Cognitive Function

  • Supports Joint Comfort & Mobility

  • Promotes Energy

  • Supports Liver Health

SAM-e is carefully crafted through a complex process that combines adenosine triphosphate (ATP) and methionine. This combination is responsible for its role in the healthy metabolism of major brain transmitters such as dopamine, serotonin, and norepinephrine. The result? 

A personal trainer for your brain, helping to support mobility, cognitive function, and memory.

In addition to supporting mood health, SAM-e is also a champion for joint health. It acts as a trusty sidekick, aiding in the production of cartilage and keeping your joints in prime condition. If you're dealing with bothersome joint discomfort or stiffness, SAM-e might just be the secret weapon you've been searching for.
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  • A personal trainer for your brain, helping to support mobility, cognitive function, and memory.
  • A personal trainer for your brain, helping to support mobility, cognitive function, and memory.
In multiple studies, SAM-e supplements have shown effectiveness in reducing common morning stiffness, alleviating everyday pain and swelling, supporting range of motion, and boosting walking pace in adults. 

It’s always important to discuss new supplements with your doctor beforehand, especially if you have any pre-existing medical conditions or take medications.

And that's not all! SAM-e is currently the subject of ongoing research regarding its potential benefits for liver health. Preliminary studies suggest that SAM-e may play a role in supporting liver function by promoting the production of glutathione, a powerful antioxidant that helps protect against toxins and oxidative stress. 

Fortunately, the market is rich with options, covering a wide variety of SAM-e supplements. But not all SAM-e supplements are created equal! 

We want to help you in your decision-making process, which is why we compiled a list of important features to consider and what to steer clear of.

Step 1

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Step 2

Tellus facilisis donec blandit massa nibh nunc. Ipsum maecenas lobortis turpis amet volutpat sed. Sit lectus velit ac rutrum. Amet suspendisse est suspendisse dignissim euismod amet lorem amet cursus. Massa turpis vitae porttitor et.

Step 3

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What to Look For

An Enteric-Coated Tablet

Enteric coatings are designed to be resistant to stomach acid. They dissolve only at a higher pH, typically around pH 5-7, which is found in the small intestine. This protects the SAM-e molecule from degradation and allows for more efficient absorption and bioavailability. .

A Reputable Manufacturer

Reputable manufacturers adhere to strict quality standards and implement rigorous quality control measures throughout the production process. This includes using high-quality ingredients, employing proper manufacturing practices, and conducting thorough testing to ensure potency, purity, and freedom from contaminants.

Clear and Complete List of Ingredients

Avoid supplements with hidden ingredients. The label should clearly list all ingredients, including fillers, binders, and excipients. Look for products that only contain SAMe and minimal inactive ingredients.

Watch Out For

Contraindication Warning

Consult with your physician before using this product if you are taking antidepressant medications. Individuals diagnosed with bipolar disorder should not take SAMe for depressive symptoms without the supervision of a healthcare provider, as it may potentially worsen symptoms of mania.

Too Many Ingredients

Supplements should only include the necessary ingredients to form the tablet or capsule. Other ingredients might be unnecessary fillers/additives.

Marketed Via Mass Emails

Avoid supplements marketed heavily in unfamiliar languages or through mass emails.

The Brilliant Process

How We Choose Products

Like you, we’re picky about products — and serious about quality. 

Whether we’re featuring an award-winning product from one of our five beauty and wellness brands — or somebody else’s — a Brilliant recommendation doesn’t see the light of day until it has been medically reviewed for accuracy and has fulfilled our Brilliant Criteria.

At Brilliant, we’re not afraid to highlight and celebrate other brands who are doing things right.

Brilliant Criteria

We take great care in handpicking high-quality products to feature on Brilliant. Here’s how we choose them:
  • Research-Based Ingredients: We dig deep into the latest research and look for products that contain science-based ingredients for optimal impact.
  • Pure, Holistic Formulas: We prioritize products that contain clean, wholesome ingredients shown to be effective. A product should only contain what it needs and nothing else — period.
  • Brand Credibility: Each product on our list is produced by a company with trusted credibility. We've also verified that each brand adheres to labeling requirements set forth under current Good Manufacturing Practices (cGMP).
  • Value: We evaluate products based on industry averages and price per serving or application. We also consider quantity and return policy.

Why Trust Us?

As veteran leaders in the wellness space with an award-winning brand portfolio of 100+ health and beauty products, we are committed to honesty and transparency, providing unbiased insights into the benefits and limitations of the information and products we evaluate — including our own. Every Brilliant Buying Guide is thoroughly vetted for medical accuracy prior to publication.

With our discerning selection process, you can feel confident that the products we recommend meet the highest benchmarks of quality, transparency, and efficacy. If we wouldn’t use a product ourselves, it’s not Brilliant.
Now that you know what to look for and avoid in a quality SAM-e supplement, it’s time to shop! 

Check out our Brilliant recommendations below.
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2024’s Must-Have SAM-e Supplements

What is lorum ipsum?

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What is lorum ipsum?

Tellus facilisis donec blandit massa nibh nunc. Ipsum maecenas lobortis turpis amet volutpat sed. Sit lectus velit ac rutrum. Amet suspendisse est suspendisse dignissim euismod amet lorem amet cursus. Massa turpis vitae porttitor et.

What is lorum ipsum?

Tellus facilisis donec blandit massa nibh nunc. Ipsum maecenas lobortis turpis amet volutpat sed. Sit lectus velit ac rutrum. Amet suspendisse est suspendisse dignissim euismod amet lorem amet cursus. Massa turpis vitae porttitor et.

What is lorum ipsum?

Tellus facilisis donec blandit massa nibh nunc. Ipsum maecenas lobortis turpis amet volutpat sed. Sit lectus velit ac rutrum. Amet suspendisse est suspendisse dignissim euismod amet lorem amet cursus. Massa turpis vitae porttitor et.

The Brilliant Choice
Doctor’s Best®

4.5/5 from 3,318 Amazon ratings

Doctor's Best Double-Strength SAM-e product box

The Brilliant Choice
Doctor’s Best®

4.5/5 from 3,318 Amazon ratings

What We Like:

    • 400 mg 
    • Enteric coated for absorption 
    • Well-established reputation
    • Soy free
    • Gluten-free
    • Non-GMO 
    • 60-day return policy

Room To Improve:

    • Not dairy free

Final Thoughts

SAM-e (S-Adenosyl-L-Methionine) is a naturally occurring compound in the body involved in various important biochemical processes. Depletion of SAM-e levels, which can occur due to factors like diet or aging, may be associated with certain emotional imbalances. 

Doctor's Best SAM-e utilizes a high-quality form of SAM-e with a sustained-release delivery system designed to support gastrointestinal comfort and absorption. Each tablet contains 400 mg of active SAM-e, a potent dose to provide support for healthy emotional well-being and mobility.

Doctor's Best offers a 60-day return policy for your satisfaction.

Product Specs

  • 60 tablets per bottle (60 servings) 
  • SAM-e (S-Adenosyl-L-Methionine disulfate p-toluensulfonate) (400 mg) 
  • Gluten-Free, Soy Free, Vegan, Non-GMO
  • Price: $$
Learn More

Fan Favorite:
Nature Made®

4.4/5 from 2,845 Amazon ratings

Nature Made SAM-e product box

Fan Favorite:
Nature Made®

4.4/5 from 2,845 Amazon ratings

What We Like:

    • 400 mg 
    • Enteric coated for absorption 
    • Well-established reputation
    • Gluten-free
    • 30-day return policy

Room To Improve:

    • Not dairy free
    • Not soy free
    • Not non-GMO

Final Thoughts

Nature Made® SAM-e Complete® provides 400mg of active SAM-e per serving, a potential source of support for emotional well-being in some individuals. Early research suggests daily use for 7-14 days may contribute to maintaining emotional balance, but individual results may vary.

Additionally, SAM-e contains sulfur, a component of joint tissues. Some studies suggest SAM-e may offer temporary support for joint comfort, particularly when combined with other lifestyle measures like staying active and maintaining a healthy diet. However, it's important to remember that SAM-e is not a substitute for a healthy lifestyle or medical advice. If you have concerns about your emotional well-being or joint health, consult your healthcare provider.

Product Specs

  • 36 tablets per bottle (36 servings) 
  • SAM-e (S-Adenosyl-L-Methionine disulfate p-toluensulfonate) (400 mg) 
  • Gluten-Free
  • Price: $$$
Learn More

Rising Star:
Jarrow Formulas®

4.4/5 from 1,080 Amazon ratings

Jarrow Formulas Vegan Naturally Derived SAMe product box

Rising Star:
Jarrow Formulas®

4.4/5 from 1,080 Amazon ratings

What We Like:

    • Enteric coated for absorption 
    • Well-established reputation
    • Soy & dairy free
    • Gluten-free
    • Non-GMO 
    • 60-day return policy

Room To Improve:

    • 200 mg

Final Thoughts

Jarrow Formulas SAMe 200 provides a concentrated source of S-Adenosyl-L-Methionine (SAMe). This dietary supplement utilizes enteric-coated tablets, which dissolve in the intestine, to deliver 200 mg of active SAM-e per serving.

Studies suggest SAMe may offer potential benefits for several areas, including joint health, liver function, and mood balance. However, individual results may vary. Each bottle contains 60 full-potency tablets. Jarrow Formulas offers a 60-day return policy.

Product Specs

  • 60 tablets per bottle (60 servings) 
  • S-Adenosyl Methionine (from S-Adenosyl-L-Methionine Disulfate Tosylate) (400mg)
  • Soy Free, Dairy Free, Gluten-Free, Non-GMO, Wheat Free, Egg Free, Shellfish Free, Peanut Free, Tree Nut Free, Sesame Free
  • Price: $
Learn More

Brilliant Nod:
NOW Foods®

4.5/5 from 668 Amazon ratings

Now SAMe product bottle

Brilliant Nod:
NOW Foods®

4.5/5 from 668 Amazon ratings

What We Like:

    • 400 mg 
    • Well-established reputation
    • Soy & dairy free
    • Gluten-free
    • 30-day return policy

Room To Improve:

    • Not enteric coated 
    • Not non-GMO

Final Thoughts

Regarded as a leader in the industry since 1968, NOW Foods prioritizes quality, sustainability, and transparency. Their stabilized SAMe oval tablets are a smaller tablet, making them easier to take for those who have issues with with larger capsules. NOW Foods supplements are all Gluten-Free, Dairy Free, Egg Free, Soy Free, Sugar Free, and suitable for vegans/vegetarians. With NPA A-rated GMP certification, NOW Foods’ manufacturing process ensures quality.

NOW Foods vitamins and supplements are regarded for their affordability, making them a budget-friendly option. NOW Foods has a 30-day return policy.

Product Specs

  • 60 [tablets] per bottle (60 servings) 
  • S-Adenosyl-L-Methionine (from S-Adenosyl-L-Methionine Disulfate Tosylate) (400 mg) 
  • Wheat Free, Gluten-Free, Soy Free, Milk Free, Egg Free, Fish Free, Shellfish Free, Sesame Free
  • Price: $$
Learn More

One to Watch:
Source Naturals®

3.9/5 from 30 Amazon ratings

Source Naturals SAMe product box

One to Watch:
Source Naturals®

3.9/5 from 30 Amazon ratings

What We Like:

    • 400 mg 
    • Enteric coated for absorption 
    • Well-established reputation
    • Soy & dairy free
    • Gluten-free

Room To Improve:

    • Limited 30-day return policy
    • Not non-GMO

Final Thoughts

Source Naturals is a trusted brand with over 40 years of experience in promoting optimal health. Their Bio-Aligned Formulas® bring alignment to your body for comprehensive support.



Source Naturals SAMe is a stable, bioavailable form of S-adenosyl-L-methionine and the capsules are enteric-coated and blister-packed to ensure ingredient effectiveness. Suitable for vegetarians.

SAMe supports joint comfort, mobility, and mental well-being by promoting healthy cartilage formation and aiding in the synthesis of proteins and neurotransmitters. Source Naturals offers a limited 30-day return policy.

Product Specs

  • 30 tablets per bottle (30 servings) 
  • S-Adenosyl-L-Methionine (from 800 mg of S-Adenosyl-L-Methionine Disulfate Tosylate) (400 mg) 
  • Yeast Free, Dairy Free, Egg Free, Gluten-Free, Soy Free, Wheat Free, Sugar Free, Preservative Free, Free of Artificial Additives. 
  • Price: $$$
Learn More

Frequently Asked Questions

What should you not take with SAM-e?

When taking SAM-e, it's important to be aware of potential interactions with other medications and supplements.

Here's what to avoid:

Serotonin Elevators: Combining SAM-e with certain antidepressants like SSRIs or SNRIs, St. John's Wort, or MAOI medications can dangerously increase serotonin levels and lead to serotonin syndrome, causing agitation, anxiety, tremors, and other serious symptoms.

Blood Thinners: Blood thinners like warfarin or heparin may interact with SAM-e, increasing bleeding risk.

Other Medications: Dextromethorphan, a cough suppressant, can trigger anxiety or restlessness when paired with SAM-e. Similarly, SAM-e might reduce the effectiveness of levodopa, a Parkinson's disease medication.

Supplement Overlap: Combining SAM-e with another serotonin-boosting supplement like 5-HTP can also lead to serotonin syndrome.

General Safety Precautions: Always consult your doctor before taking SAM-e, especially if you have existing health conditions or are on medication. Start with a low dose and gradually increase as needed, following your doctor's guidance. Be aware of potential side effects like nausea, headache, stomach upset, and anxiety. If you experience any severe side effects, stop taking SAM-e and consult your doctor immediately.

Is it better to take SAM-e at night or in the morning?

For optimal results, it is recommended to take SAM-e on an empty stomach. Due to its potential stimulating effects, it is advisable to take it earlier in the day to avoid any potential disruption to your sleep patterns.

How long does it take for SAM-e to work for mood support?

The time it takes for SAM-e to work for mood support can vary from person to person. Some individuals may start experiencing benefits within a few days, while for others, it may take several weeks. It’s important to note that SAM-e is not an immediate solution and its effects may accumulate gradually over time. It’s always recommended to consult with a healthcare professional for personalized advice and to determine the appropriate duration for achieving the desired mood support.
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Citations

1. Anstee, Quentin M, and Christopher P Day. “ Journal of Hepatology vol. 57,5 (2012): 1097-109. doi:10.1016/j.jhep.2012.04.041
2. Berigan, Timothy R.. Primary care companion to the Journal of Clinical Psychiatry vol. 4,4 (2002): 159. doi:10.4088/pcc.v04n0408b
3. Bottiglieri, Teodoro. The American Journal of Clinical Nutrition vol. 76,5 (2002): 1151S-7S. doi:10.1093/ajcn/76/5.1151S
4. Cuomo, Alessandro et al. Annals of General Psychiatry vol. 19 50. 5 Sep. 2020, doi:10.1186/s12991-020-00298-z
5. De Silva, Vijitha et al. Rheumatology (Oxford, England) vol. 50,5 (2011): 911-20. doi:10.1093/rheumatology/keq379
6. Hosea Blewett, Heather Joy. Critical Reviews in Food Science and Nutrition vol. 48,5 (2008): 458-63. doi:10.1080/10408390701429526
7. Kim, Jinhyun et al. Clinical Therapeutics vol. 31,12 (2009): 2860-72. doi:10.1016/j.clinthera.2009.12.016
8. Mato, José M, and Shelly C Lu. Hepatology (Baltimore, Md.) vol. 45,5 (2007): 1306-12. doi:10.1002/hep.21650
9. Papakostas, George I. The Journal of Clinical Psychiatry vol. 70 Suppl 5 (2009): 18-22. doi:10.4088/JCP.8157su1c.04
10. Pascale, Rosa M et al. Cells vol. 11,3 409. 25 Jan. 2022, doi:10.3390/cells11030409
11. NCCIH. National Center for Complementary and Integrative Health, www.nccih.nih.gov/health/sadenosyllmethionine-same-in-depth.
12. Sharma, Anup et al. The Journal of Clinical Psychiatry vol. 78,6 (2017): e656-e667. doi:10.4088/JCP.16r11113
13. Soeken, Karen L et al. The Journal of Family Practice vol. 51,5 (2002): 425-30.
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