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2025’s Highly-Rated Supplements for Hormonal Balance & Menopause Symptoms

What to look for in an effective hormone balance supplement + how it can help reduce PMS and menopause symptoms.

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Written by Brilliant Staff

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Fact Checked by Melissa Mitri, MS, RD

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Did you know the human body produces over 50 hormones that secretly shape how we think and feel?

Over time, our bodies naturally produce fewer hormones which can have a negative impact on our day-to-day lives. 

This includes mood swings, hot flashes, non-cystic acne, bloating, cramps, fatigue, plus weight and libido changes–all uncomfortable symptoms that are associated with PMS and menopause.

That's why it's so important to maintain hormonal balance. Doing so can improve mood regulation, sleep quality, stress management, and sexual health.

Fortunately, in recent years scientists have discoveredingredients that can help balance hormones and reduce PMS & menopause symptoms.

Key Benefits of Hormone Balance Supplements

Effective supplements will infuse their formulas with a potent blend of ingredients like myo-inositol and d-chiro-inositol, which work together to support healthy estrogen levels, consistent monthly cycles, while helping to regulate mood and maintain healthy cholesterol levels.

Targeting the most common symptoms of menopause, including hot flashes, mood swings, sleep disturbances, non-cystic acne, and bloating, potent hormone balance supplements are formulated with naturally-sourced extracts like chaste tree berry and maca root that can provide aid for perimenopausal and menopausal women.

Highly-rated hormone balance formulas can reduce the uncomfortable effects of PMS, such as fatigue, cramps, and greasy hair. Incorporating holistic extracts like berberine promotes consistent energy levels and a healthy libido.

A quality formula will help balance estrogen and progesterone levels, which can reduce food cravings linked to PMS. Supplements formulated with berberine and vitamin B6 stand out since these ingredients support bloating reduction before and during monthly cycles.

One common symptom of PMS, perimenopause, and menopause is mood swings, which can have an impact on sleep, concentration, and libido. Some hormone supplements feature maca root, which encourages emotional and mental well-being, while enhancing mental clarity and natural energy levels.

So, what’s your best bet when shopping for a hormone supplement? Our recommendation is to stick with scientifically formulated products that have been third-party tested for high standards and quality control.


Here’s a shortlist of ingredients to look for in optimal hormone health supplements.

Key Ingredients in a High-Quality Hormone Supplement

Myo-inositol is an essential component in any quality hormone balance supplement, since its main objective is supporting healthy hormone levels, specifically estrogen, which aids in proper and consistent ovarian health.

D-chiro-inositol can play a vital role in promoting consistent metabolic health, while also helping insulin and supporting balanced emotional wellness.

Berberine is a naturally-sourced extract that has shown benefits in supporting weight management, energy levels, and a healthy libido, all of which can be negatively impacted by PMS.

A key holistic ingredient in helping to reduce the uncomfortable symptoms of PMS and menopause, such as hot flashes, occasional sleep issues, non-cystic acne, cramps, and mood swings. Chaste tree berry supports regular monthly cycles and overall metabolic health.

Staying alert after another restless night due to hormonal shifts or menopausal symptoms can be a struggle. A naturally-derived ingredient, maca root promotes mental clarity, emotional balance, consistent energy levels, and may support a healthy libido.

Watch Out For

Some hormone supplements are formulated with an all-in-one proprietary blend, which tends to obscure the actual amount of each ingredient in their formula. Instead, search for products that provide clear and concise amounts of each ingredient for enhanced transparency and effectiveness.

An effective and potent hormone supplement typically won’t use unnecessary fillers or additives in its formula. The ingredients in a scientifically formulated product will help manage the fluctuation of normal hormone levels, due to menopause and PMS, and deliver consistent and healthy results you can rely on.

A product that has been third-party tested ensures there are no metals or contaminants, and must always be awarded a passing certificate of analysis before being placed in circulation. This is based on strict U.S. government standards, compliance, and quality control.

Now that you know what to look for and avoid in hormone balance supplements, it’s time to shop! Check out our Brilliant recommendations below, including our own Live Conscious® Beyond HormoneTM.

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2025’s Must-Have Hormone Health Supplements

The Brilliant Choice:

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4.5/5 from 45 website ratings

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What We Like:

  • Icon Myo-inositol
  • Icon D-chiro-inositol
  • Icon Berberine
  • Icon Gluten free
  • Icon Non-GMO
  • Icon Third-party tested
  • Icon 365-day money-back guarantee
  • Icon Manufactured in the USA with global ingredients

Room To Improve:

  • Icon Not always in stock

Final Thoughts

Beyond Hormone from Live Conscious is fortified with myo-inositol, d-chiro-inositol, berberine, chaste tree berry, maca root, and high potency vitamin B6 to ensure you receive extra support for hormonal balance, menopause, and PMS.

Our science-backed formula was developed with meaningful doses, rather than an all-in-one proprietary blend. It helps reduce hot flashes, mood swings, cramps, non-cystic acne, while promoting metabolic, ovarian, and emotional wellness, consistent weight management, a healthy libido, and mental clarity.

Product Specs

  • 90 capsules per bottle (30 servings) 
  • Myo-inositol (1500 mg), d-chiro-inositol (37.5 mg), berberine HCI bark extract (500 mg), chaste tree berry extract (30 mg), maca root extract (85 mg), DIM (100 mg), vitamin B6 (3.4 mg), folate (as folic acid 240 mcg)
  • Gluten-free, soy-free, dairy-free, non-GMO
  • Price: $$$

Runner Up:

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4.7/5 from 220 website ratings

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What We Like:

  • Icon Myo inositol
  • Icon D-chiro-inositol
  • Icon Gluten free
  • Icon Non-GMO
  • Icon Third-party tested
  • Icon 90-day return policy
  • Icon Manufactured in the USA with local & global ingredients

Room To Improve:

  • Icon Does not contain berberine

Final Thoughts

Wholesome Story stands out in the hormone balance supplement space with 2,000 mg of myo-inositol and 50 mg of d-chiro-inositol (40:1 ratio). We appreciate this formula, since both inositols can play a significant role in promoting regular and proper metabolic and ovarian health. One downside to this product is that it does not contain berberine.

Product Specs

  • 120 capsules / bottle (30 servings)
  • Myo-inositol (2000 mg), d-chiro-inositol (50 mg), vitamin D3 (25 mcg), folate (500 mcg DFE)
  • Gluten-free, soy-free, dairy-free, non-GMO
  • Price: $

*We earn a commission if you click on this link to make a purchase of Wholesome Story.

Brilliant Nod:

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5/5 from 14k+ website ratings

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What We Like:

  • Icon Berberine
  • Icon Gluten free
  • Icon Non-GMO
  • Icon Third-party tested
  • Icon 180-day return policy
  • Icon Manufactured in the USA with local & global ingredients

Room To Improve:

  • Icon Proprietary blend
  • Icon Does not contain myo- or d-chiro-inositol

Final Thoughts

Wholesome Story stands out in the hormone balance supplement space with 2,000 mg of myo-inositol and 50 mg of d-chiro-inositol (40:1 ratio). We appreciate this formula, since both inositols can play a significant role in promoting regular and proper metabolic and ovarian health. One downside to this product is that it does not contain berberine.

Product Specs

  • 120 capsules / bottle (30 servings)
  • Myo-inositol (2000 mg), d-chiro-inositol (50 mg), vitamin D3 (25 mcg), folate (500 mcg DFE)
  • Gluten-free, soy-free, dairy-free, non-GMO
  • Price: $

*We earn a commission if you click on this link to make a purchase of Bulk Supplements

Influencer Favorite:

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5/5 from 2 Amazon ratings

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What We Like:

  • Icon Myo-inositol
  • Icon Gluten free
  • Icon Manufactured in the USA with local & global ingredients

Room To Improve:

  • Icon Does not contain d-chiro-inositol or berberine
  • Icon 30-day return policy

Final Thoughts

Unlike the other products on this list, Alani Nu’s Balance features l-glutathione, which helps support skin complexion by aiding in hydration. It also includes chromium for blood sugar management and ALA–which pairs well with myo-Inositol to support normal insulin-sensitivity. We’re not thrilled with their 30-day return policy, since it can take up to several months for a supplement to yield results.

Product Specs

  • 120 capsules / bottle (30 servings) 
  • Myo-inositol (2g), diindolylmethane (DIM) (150 mg), folate (400 mcg DFE), chromium (120 mcg), setria l-glutathione (250 mg), sodium r-alpha lipoic acid (ALA) (100 mg)
  • Gluten-free
  • Price: $$

*We earn a commission if you click on this link to make a purchase of Alani Nu’s Balance.

Simple Pick:

star rating

4.5/5 from 72 website ratings

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What We Like:

  • Icon Gluten free
  • Icon Non-GMO
  • Icon Third-party tested

Room To Improve:

  • Icon Proprietary blend
  • Icon Does not myo-inositol, d-chiro-inositol, or berberine
  • Icon 30-day return policy

Final Thoughts

While Ancient Nutrition doesn’t feature either inositol in its Women’s Hormones formula, it does provide chaste tree berry, reishi, and ashwagandha, ingredients that help support reproductive and emotional health. Reishi, in particular, is becoming increasingly popular in supplementation to help promote immune health.

Product Specs

  • 60 capsules/bottle (30 servings) 
  • Organic reishi mycelium, organic fermented chaste tree berry, organic ashwagandha root and leaf extract, organic fermented black cohosh root, organic fermented schisandra berry  
  • Gluten-free, non-GMO
  • Price: $

*We earn a commission if you click on this link to make a purchase of Ancient Nutrition.

Frequently Asked Questions

Powerful hormone supplements can help reduce hot flashes, mood swings, cramps, non-cystic acne, and other uncomfortable menopausal symptoms along with a healthy diet and lifestyle. Potent naturally-occurring ingredients like chaste tree berry, berberine, and maca root in an effective formula promote consistent mood and body temperature, better sleep, clearer skin, and less cramping.

A scientifically formulated product will support healthy hormone balance, menopause and PMS support, metabolic and ovarian health, bloating reduction, mental clarity, positive mood, consistent energy levels, and weight management.

Certain products will include berberine, a key ingredient that helps promote healthy weight management. The formula may also feature vitamin B6, which aids digestion and supports bloating reduction.

The Brilliant Process

Like you, we’re picky about products — and serious about quality

Whether we’re featuring an award-winning product from one of our five beauty and wellness brands — or somebody else’s — a Brilliant recommendation doesn’t see the light of day until it has been medically reviewed by our Fact Checkers for accuracy and has fulfilled our Brilliant Criteria. 

At Brilliant, although we often feature products that we sell, we’re not afraid to highlight and celebrate other brands who are doing things right.

We take great care in handpicking high-quality products to feature on Brilliant. Here’s how we choose them: 

  • High-Quality Ingredients: We dig deep into the latest research and look for products that contain comprehensive ingredients for optimal impact. 
  • Pure, Holistic Formulas: We prioritize products that contain clean, wholesome ingredients. A product should only contain what it needs and nothing else—period.
  • Brand credibility: Each product on our list is produced by a company with trusted credibility. We've also verified that each brand adheres to labeling requirements set forth under current Good Manufacturing Practices (cGMP).
  • Value: We evaluate products based on industry averages and price per serving or application. We also consider quantity and return policy. 

As veteran leaders in the wellness space with an award-winning brand portfolio of 100+ health and beauty products, we are committed to honesty and transparency, providing thoughtful insights into the benefits and limitations of the information and products we evaluate — including our own. Every Brilliant Buying Guide is thoroughly vetted for medical accuracy by our Fact Checkers prior to publication.  

With our discerning selection process, you can feel confident that the products we recommend meet the highest benchmarks of quality, transparency, and efficacy. If we wouldn’t use a product ourselves, it’s not Brilliant

  1. Starka, L; Duskova, M. Physiol Res, U.S. National Library of Medicine, ncbi.nlm.nih.gov/pmc/articles/PMC8603735. Accessed 1 Sep. 2020.2.
  2. Professional, Cleveland Clinic medical. my.clevelandclinic.org/health/drugs/25173-inositol. Accessed 11 Nov. 2023.
  3. Pintaudi B; Di Vieste G; Bonomo M. International Journal of Endocrinology, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/27807448. Accessed 11 Nov. 2023.
  4. WebMD, www.webmd.com/vitamins/ai/ingredientmono-1126/berberine. Accessed 11 Nov. 2023.
  5. Www.urmc.rochester.edu, www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=19&contentid=ChasteTree#:~:text=Chaste%20tree%20has%20been%20used. Accessed 11 Nov. 2023.
  6. Healthline, 30 Oct. 2016, www.healthline.com/nutrition/benefits-of-maca-root#libido-and-fertility. Accessed 11 Nov. 2023