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5 Must-Have Cholesterol Supplements

Not ready to swear off your favorite foods? With the right cholesterol support, you may not have to.

  • Written by: Brilliant Staff
  • Fact Checked by: Dr. Pravesh Saini
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Cholesterol supplements are like personal trainers for your heart — minus all the sweat and heavy lifting.

Not only are they great for maintaining healthy cholesterol, blood circulation, and energy levels, but they can also give you a greater sense of control over your cardiovascular health. 

Best of all, cholesterol supplements work with any lifestyle — something to consider before you gut all your guilty pleasures.

Benefits

  • Cardiovascular Support

  • Blood Pressure Maintenance

  • Balanced Cholesterol Profile

  • Promotes Circulation

  • Helps Combat Occasional Fatigue

Many of today’s cholesterol supplements include ingredients that have been used for centuries to support cardiovascular health, digestive concerns, and immune health. 

One such ingredient is called bergamot, an ancient fruit native to the region of Calabria in Italy.

Residents of the region are known to have long lifespans and a high quality of life, and despite their high-carb diets, also have extraordinary cardiovascular health.

So, what’s their secret?

Experts believe bergamot may help contribute to residents’ longevity and overall heart health. 

According to one study, bergamot contains a special enzyme with cholesterol-regulating properties, with evidence to suggest it can help maintain healthy LDL cholesterol.

In its extracted form, bergamot is far more concentrated and potent, offering potentially greater health benefits.
  • In its extracted form, bergamot is far more concentrated and potent, offering potentially greater health benefits.
  • In its extracted form, bergamot is far more concentrated and potent, offering potentially greater health benefits.
Moreover, combining bergamot with synergistic ingredients like niacin and garlic, may also promote additional benefits related to blood flow, cholesterol, and a happy heart.

A quality cholesterol supplement uses a blend of science-backed ingredients like those mentioned above. 

But a long list of ingredients doesn’t always mean you’re getting a superior product. There are plenty of supplements with unnecessary add-ons and fillers — often as a way to inflate the asking price or to make up for low doses of key ingredients. 

So, what should you look for in your supplement? Our advice? Keep it simple. 

Here's our shortlist of key ingredients and doses to look for in your cholesterol supplement:

Step 1

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Step 2

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Step 3

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Key Ingredients

Clinically Studied Bergamot Extract

Bergamot contains antioxidants related to cholesterol production and arterial health. And it's even more effective in the form of a patented extract called Bergavit® — a clinically-studied form of bergamot that supports a balanced cholesterol profile and your overall heart health.

Recommended dose: 550 mg

Niacin

Niacin is a powerful form of vitamin B3 that helps convert nutrients into cellular energy. Its unique enzymes have been found to influence cholesterol and healthy triglyceride levels already within a normal range. 

Recommended dose: 400 mg

Garlic Extract

Allicin, a unique antioxidant found in garlic, promotes strong circulation, helping maximize support for cholesterol that's already within a normal range. 

Recommended dose: 130 mg

Olive Leaf Extract

Olive leaf extract is a unique botanical compound that promotes healthy blood lipid levels and supports flexible blood vessels. 

Recommended dose: 50 mg

Watch Out For

Red Yeast Rice

Red yeast rice is a common ingredient found in many cardiovascular supplements. However, it can also lead to some undesirable side effects, including headaches, nausea, diarrhea, and overall digestive discomfort.

The Brilliant Process 

How We Choose Products

Like you, we’re picky about products — and serious about quality

Whether we’re featuring an award-winning product from one of our five beauty and wellness brands — or somebody else’s — a Brilliant recommendation doesn’t see the light of day until it has been medically reviewed for accuracy and has fulfilled our Brilliant Criteria.

At Brilliant, we’re not afraid to highlight and celebrate other brands who are doing things right.

Brilliant Criteria

We take great care in handpicking high-quality products to feature on Brilliant. Here’s how we choose them:
  • Research-Based Ingredients: We dig deep into the latest research and look for products that contain science-based ingredients for optimal impact.
  • Pure, Holistic Formulas: We prioritize products that contain clean, wholesome ingredients shown to be effective. A product should only contain what it needs and nothing else — period.
  • Brand credibility: Each product on our list is produced by a company with trusted credibility. We've also verified that each brand adheres to labeling requirements set forth under current Good Manufacturing Practices (cGMP).
  • Value: We evaluate products based on industry averages and price per serving or application. We also consider quantity and return policy.

Why Trust Us?

As veteran leaders in the wellness space with an award-winning brand portfolio of 100+ health and beauty products, we are committed to honesty and transparency, providing unbiased insights into the benefits and limitations of the information and products we evaluate — including our own. Every Brilliant Buying Guide is thoroughly vetted for medical accuracy prior to publication.

With our discerning selection process, you can feel confident that the products we recommend meet the highest benchmarks of quality, transparency, and efficacy. If we wouldn’t use a product ourselves, it’s not Brilliant.
Now that you know what to look for and avoid in your cholesterol supplement, it’s time to shop. 

Check out our Brilliant recommendations below, including CholestMD from our in-house brand, 1MD Nutrition®. CholestMD is endorsed by Dr. Heather Shenkman, a board-certified cardiologist.
CholestMD_-_Comparison_Chart_1c90df5d-a18a-4153-8f9d-6d56a26155fa

2024’s Must-Have Cholesterol Supplements

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What is lorum ipsum?

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What is lorum ipsum?

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What is lorum ipsum?

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What We Like:

    • Clinically studied bergamot
    • Niacin 
    • Garlic & olive leaf extract 
    • Recommended by board-certified cardiologist
    • Non-GMO
    • Made in the USA with global ingredients
    • 90-day return policy

Room To Improve:

    • Sold exclusively online

Final Thoughts

CholestMD is from our very own brand, 1MD Nutrition, and endorsed by board-certified cardiologist, Dr. Heather Shenkman. 


CholestMD is meticulously crafted with Bergavit®, a clinically studied form of bergamot, as well as niacin, garlic extract, and olive leaf extract for comprehensive cholesterol and cardiovascular support. 


Our formula is also vegan, non-GMO, and manufactured in a GMP-certified facility to ensure batch-to-batch purity and consistency. 


If for any reason you are not satisfied with CholestMD, we offer a 100% satisfaction, 90-day money-back guarantee.

Product Specs

  • 60 capsules per bottle (30 servings) 
  • Niacin (40 mg) 
  • Bergavit® bergamot orange fruit extract (550 mg)
  • Garlic bulb extract (130 mg)
  • Olive leaf extract (50 mg)
  • Gluten Free, Dairy Free, Peanut Free, Wheat Free, Shellfish Free, Non-GMO
  • Price: $$

What We Like:

    • Clinically studied bergamot
    • Olive leaf extract
    • Doctor formulated
    • Non-GMO
    • Made in the USA
    • Made in FDA-inspected facility
    • 365-day return policy

Room To Improve:

    • Lacks some key ingredients

Final Thoughts

Durable Heart is formulated with 1000 mg of clinically studied bergamot (Bergamonte®) and 100 mg of clinically studied olive leaf extract to support healthy cholesterol and cardiovascular function, as well as vitamin C for added immune support. 


Like CholestMD, Durable Heart is also doctor-formulated and non-GMO, and is manufactured in an FDA-inspected facility to ensure quality and consistency from batch to batch. 


While there’s a lot to like about this formula, it also lacks heart-friendly ingredients like niacin and garlic extract. Durable is backed by a rock-solid, 365-day return policy.

Product Specs

  • 60 capsules per bottle (30 servings) 
  • Bergamote® bergamot orange fruit extract (1000 mg) 
  • Olefresh™ olive leaf extract (100 mg)
  • Vitamin C (50 mg)
  • Non-GMO, Vegetarian
  • Price: $$

*We earn a commission if you click on this link to make a purchase of Durable

What We Like:

    • Bergamot
    • Niacin
    • Olive leaf extract
    • Garlic extract
    • Non-GMO
    • GMP-certified
    • Made in the USA

Room To Improve:

    • Does not use clinically studied bergamot
    • Unclear return policy

Final Thoughts

Aumeto’s CholestShield contains powerful key ingredients like bergamot, niacin, and olive leaf extract. It also contains black chokeberry extract and a 300 mg proprietary blend consisting of ingredients like garlic extract, artichoke leaf extract, and ginger, which may also help support healthy cardiovascular function. 


While their formula does not use a clinically studied version of bergamot extract, and while dosages for ingredients like niacin and garlic extract are somewhat low on the potency spectrum, CholestShield is still a competitive product. At just under $15 per bottle, it takes the cake for the lowest price point. 


CholestShield’s formula is also non-GMO, third-party tested, and made in the USA. Unfortunately, a clear return policy is not listed on their website.

Product Specs

  • 90 capsules (45 servings) 
  • Bergamot (500 mg)
  • Black chokeberry fruit extract (200 mg)
  • Olive leaf extract (100 mg)
  • Niacin (100mg)
  • CholestShieldXXI™ compound with garlic extract (300 mg)
  • Non-GMO 
  • Price: $

*We earn a commission if you click on this link to make a purchase of Aumeto

What We Like:

    • Clinically studied bergamot  
    • Garlic extract
    • Olive leaf extract
    • Gluten free
    • Non-GMO
    • Made in the USA
    • Good manufacturing practices
    • 60-day return policy

Room To Improve:

    • Formula potency

Final Thoughts

Cholesterol Heart Health from UpNourish contains all of our recommended ingredients, including clinically studied Bergavit®.  


Their formula also includes cholesterol-friendly ingredients, such as CoQ10, turmeric, and omega-3 fish oil. Additionally, this product is third-party tested, gluten free, non-GMO, and made in the USA.


While UpNourish boasts a commendable variety of ingredients, the dosages for key ingredients are below recommended levels, which may prevent this product from being as effective as others on our list.


Cholesterol Heart Health is backed by a healthy, 60-day return policy.

Product Specs

  • 120 softgels (60 servings) 
  • Bergavit® bergamot orange fruit extract (187.5 mg)
  • Black garlic extract (25 mg)
  • Niacin (12.5 mg)
  • Plant sterol esters (650 mg)
  • CoQ 10 (15 mg)
  • Olive leaf extract (50 mg)
  • Turmeric (25 mg)
  • Fish oil (430 mg)
  • Non-GMO, Gluten Free 
  • Price: $

*We earn a commission if you click on this link to make a purchase of UpNourish

What We Like:

    • Clinically studied bergamot 
    • Niacin
    • Doctor formulated
    • Non-GMO
    • Made in the USA
    • Good manufacturing practices
    • 365-day money-back guarantee

Room To Improve:

    • Lacks some key ingredients

Final Thoughts

HFL’s’ Cholesterol Optimizer supplement is both doctor formulated and an Amazon’s Choice product. It’s made with clinically studied bergamot (Bergavit®) and niacin. 


While it lacks key ingredients like olive leaf extract and garlic extract, it offers a host of other naturally derived ingredients like artichoke leaf extract, a plant sterol complex, and a potent blend of vitamins that may promote additional cardiovascular benefits. 


Cholesterol Optimizer is also non-GMO, vegan, and third-party tested to ensure purity and consistency.


HFL also offers an impressive, 365-day money-back guarantee, plus $100, if you are not completely satisfied.

Product Specs

  • 80 capsules per bottle (40 servings)
  • Bergavit® Bergamot (400 mg)
  • Niacin (170 mg) 
  • CardioAid®-S Plant Sterols Complex (400 mg)
  • Novasoy® Soy Isoflavones (20 mg)
  • Pycrinil® Artichoke Leaf Extract (200 mg)
  • Pantesin® d-Pantethine (150 mg)
  • Vitamin B6 (29.88 mg)
  • Vitamin B2 (6 mg)
  • Vitamin B12 (250 mcg)
  • Folate (680 mcg)
  • Vitamin B5 (9 2mg)
  • Vitamin E (2.4 mg)
  • Co-Q10 (30 mg)
  • Choline Bitartrate (250 mg)
  • Non-GMO, Vegan 
  • Price: $$

*We earn a commission if you click on this link to make a purchase of Health, Fitness, and Longevity.

Frequently Asked Questions

Can cholesterol supplements replace statins or prescription medication?

No, cholesterol supplements are not a replacement for any prescription medication. Always consult your physician before using this or any product.

What foods are cholesterol-friendly?

Balancing your diet with staples such as legumes, low starch veggies, or nuts is a good way to promote and maintain healthy cholesterol levels.

Why should cholesterol supplements contain both niacin and niacinamide?

Although the two are used interchangeably, niacin and niacinamide have different properties. When ingested, niacin is converted to niacinamide, and that niacinamide is then converted to a metabolically active form: the coenzyme nicotinamide adenine dinucleotide (NAD), which is an important part of our energy production cycle.

The addition of niacinamide boosts the performance of all of the essential biochemical functions of niacin, while also not contributing to the “flushing reaction” commonly experienced with niacin.

Citations

  1. Mollace, Vincenzo et al. Fitoterapia vol. 82,3 (2011): 309-16. doi:10.1016/j.fitote.2010.10.014
  2. C. Nauman, Mirielle, and Jeremy J. Johnson. Integrative Food, Nutrition and Metabolism, vol. 6, no. 2, Mar. 2019, https://doi.org/10.15761/ifnm.1000249.
  3. NIH Office of Dietary Supplements, U.S. Department of Health and Human Services, ods.od.nih.gov/factsheets/Niacin-HealthProfessional/. Accessed 15 Nov. 2023.
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