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5 Brilliant Liver Detox Supplements

Learn how to tackle fatigue, bloating, & brain fog with a quality daily liver cleanse.

  • Written by: Brilliant Staff
  • Fact Checked by: Ellen Landes, MS, RDN, CPT
Your liver does a lot of heavy lifting to keep you healthy and active. It aids maintaining a healthy metabolism, helps with digestion, detoxes the body, and is vital for proper blood circulation

Many of us abuse our liver without even knowing it with things like alcohol, processed foods, or frequent weight fluctuations. 

Typically, the liver does a good job of filtering out toxins

But with the number of toxins we’re all exposed to regularly, it becomes hard for your body’s filter to keep up. 

The unnecessary strain on your liver can cause unpleasant symptoms like fatigue, brain fog, and bloating. That's why a quality liver detox supplement can support your liver strength & detox process.

How To Pick A Powerful Liver Supplement From The Junk

With our constant exposure to toxins, it’s no wonder the market is flooded with supplements promising effective liver detoxification and optimal liver support.
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Key Benefits of Liver Detox Supplements

  • Liver Protection

  • Healthy Metabolism

  • Long-Lasting Energy

  • Smoother Digestion

  • Mental Clarity

Feeling Blue? Your Liver Might be the Culprit

A quality liver health formula begins supporting your body’s filter right away, and the more consistently you take it, the better you’ll feel.


While many users see results sooner, research suggests that lasting results often occur after 90 days of consistent use. Here’s what you can expect:

When Will You See Results?

A quality liver health formula begins supporting your body’s filter right away, and the more consistently you take it, the better you’ll feel.


While many users see results sooner, research suggests that lasting results often occur after 90 days of consistent use. Here’s what you can expect:

Month 1:

You may feel less discomfort as liver-nourishing nutrients start to tackle bloating and soothe your digestive system.

Month 2:

As your overall liver health starts to improve, don’t be surprised if you notice more energy and a better mood.

Month 3:

This is when peak support officially begins. In fact, some people report feeling a difference with long-lasting energy, metabolic support, and a clearer mind.

Pro Tip: Consistency is key. So, make sure to stick with a quality formula for at least 3 months.

So with all these amazing health benefits in mind, which ingredients should you look for in a liver supplement and what should you avoid? 

Our advice? Keep it simple.

What Ingredients Make a Quality Liver Detox Supplement?

N-Acetyl Cysteine

NAC helps reduce oxidative stress in the liver to keep your immune system, cells, and tissues in check. It’s also a basic building block of glutathione, which has been called “the mother of all antioxidants.” You can find it in a variety of meats, seafood, and turkey.

Patented Milk Thistle

Recent research has shown that milk thistle can help reduce oxidative stress and toxins. It can also help support liver function, maintain a healthy metabolism, and supports weight management.

Alpha Lipoic Acid

Alpha Lipoic Acid, or ALA, is recognized as an antioxidant that may assist in nutrient absorption, energy, & metabolism. Its role in liver health, particularly in detoxification, is an area of ongoing research.

Tocotrienols

Tocotrienols are a very potent form of vitamin E, or as we like to call them, supercharged vitamin E. This powerhouse ingredient can work to help cleanse your liver.

Zinc

Research has shown that zinc can help protect your liver from future stress.

Selenium

This powerful mineral is vital for helping your liver cleanse and detox itself. It can help your liver detox by encouraging the production of an antioxidant called glutathione, which can help support healthy liver tissue cells and elasticity.

Watch out for

Unnecessary Fillers

Even when a liver health supplement contains some great ingredients, it’s also important to look out for the “other” ingredients contained in their formula. 

These additional ingredients could include allergens, and dietary restricted ingredients such as animal derived ingredients, preservatives, or other additives. 

How We Choose Products

Like you, we’re picky about products — and serious about quality

Whether we’re featuring an award-winning product from one of our five beauty and wellness brands — or somebody else’s — a Brilliant recommendation doesn’t see the light of day until it has been medically reviewed for accuracy and has fulfilled our Brilliant Criteria.

At Brilliant, although we often feature products that we sell, we’re not afraid to highlight and celebrate other brands who are doing things right.

Brilliant Criteria

We take great care in handpicking high-quality products to feature on Brilliant. Here’s how we choose them:
  • Research-Based Ingredients: We dig deep into the latest research and look for products that contain science-based ingredients for optimal impact.
  • Pure, Holistic Formulas: We prioritize products that contain clean, wholesome ingredients shown to be effective. A product should only contain what it needs and nothing else — period.
  • Brand Credibility: Each product on our list is produced by a company with trusted credibility. We've also verified that each brand adheres to labeling requirements set forth under current Good Manufacturing Practices (cGMP).
  • Value: We evaluate products based on industry averages and price per serving or application. We also consider quantity and return policy.

Why Trust Us?

As veteran leaders in the wellness space with an award-winning brand portfolio of 100+ health and beauty products, we are committed to honesty and transparency, providing unbiased insights into the benefits and limitations of the information and products we evaluate — including our own. Every Brilliant Buying Guide is thoroughly vetted for medical accuracy prior to publication.

With our discerning selection process, you can feel confident that the products we recommend meet the highest benchmarks of quality, transparency, and efficacy. If we wouldn’t use a product ourselves, it’s not Brilliant.
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Now that you know what to look for and avoid in your liver health supplement, it’s time to shop. 

Check out our Brilliant recommendations below, including LiverMD® from our in-house brand, 1MD Nutrition™ and LiverWell™ from Live Conscious®. LiverMD® is formulated by board-certified gastroenterologist, Dr. David Kahana.

2024’s Must-Have Liver Detox Supplements

What We Like:

    • Get 10% Off with code 'FIRST10'
    • Clinically-studied milk thistle
    • N-acetyl cysteine
    • Alpha lipoic acid
    • Clinically-studied Vitamin E
    • Doctor-formulated
    • Good Manufacturing Practices
    • Made in the USA with global ingredients
    • 90-day return policy

Room To Improve:

    • Available only online

Final Thoughts

LiverMD is from our very own brand, 1MD Nutrition, and is formulated by board-certified gastroenterologist, Dr. David Kahana

LiverMD includes clinically-studied ingredients in its award-winning liver detox formula. Its patented vitamin E extract, TocoGaia, and patented milk thistle extract, Siliphos®, is added for its potential benefit of nutrient absorption and improving liver strength

Our formula is also vegan, non-GMO, and manufactured in a GMP-certified facility to ensure batch-to-batch purity and consistency.

If for any reason you are not satisfied with LiverMD, we offer a 100% satisfaction, 90-day money-back guarantee.

Product Specs

  • 60 capsules per bottle (30 servings) 
  • TocoGaia vitamin E extract (3.5 mg) 
  • Siliphos® milk thistle extract (160 mg)
  • N-acetyl cysteine (500 mg)
  • Alpha lipoic acid (100 mg)
  • Zinc citrate (15 mg)
  • Selenium amino acid chelate (200 mcg)
  • Gluten Free, Dairy Free, Peanut Free, Wheat Free, Shellfish Free, Non-GMO
  • Price: $$

Get 10% Off with code 'FIRST10'

What We Like:

    • Clinically studied milk thistle
    • N-acetyl cysteine
    • Vitamin E
    • Alpha lipoic acid
    • Zinc
    • Good Manufacturing Practices
    • 365-day return policy

Room To Improve:

    • Available exclusively online

Final Thoughts

LiverWell is another liver health supplement from our very own brand, Live Conscious. 

While not doctor-formulated and has a slightly lower dose of milk thistle, it still offers the same potent ingredients found in LiverMD, including 800 mg of NAC, patented milk thistle (Siliphos®), zinc, selenium, and alpha lipoic acid — all of which help detoxify the liver and fortify the immune system.

This product is manufactured in GMP-compliant facilities to ensure safety and purity in every bottle. 

All Live Conscious products are backed by a 365-day return policy, zero questions asked.

Product Specs

  • 60 capsules per bottle (30 servings) 
  • Siliphos® milk thistle extract (80 mg)
  • N-acetyl cysteine (800 mg)
  • Alpha lipoic acid (100 mg)
  • Zinc citrate (15 mg)
  • Selenium amino acid chelate (200 mcg)
  • Non-GMO, Gluten Free, Dairy Free, Soy Free, Peanut Free, Shellfish Free, Vegan
  • Price: $

What We Like:

    • Vitamin E
    • Milk thistle
    • Alpha lipoic acid
    • Doctor-formulated
    • Good Manufacturing Practices 
    • Made in the USA with global ingredients
    • Lifetime return policy

Room To Improve:

    • No NAC

Final Thoughts

OmniBiotic’s Liver Reboot contains powerful key ingredients like vitamin E, milk thistle, and alpha lipoic acid to support liver health. 

It also contains black chokeberry extract and a 300 mg blend consisting of ingredients like dandelion root, ginger, and grapeseed, which may also help support healthy liver function

While their formula does not use NAC or a clinically studied form of milk thistle, it contains a higher dose of ALA to support nutrient absorption

Liver Reboot is also non-GMO, vegan, made in the USA with globally sourced ingredients, and backed by a stellar lifetime money-back guarantee.

Product Specs

  • 60 capsules (30 servings) 
  • Vitamin E (10 mg)
  • Vitamin C (30 mg)
  • Zinc (10 mg)
  • Milk thistle (500 mg) 
  • Artichoke leaf (150 mg)
  • Schisandra fruit powder (150 mg)
  • Alpha lipoic acid (125 mg)
  • Dandelion root (125 mg) 
  • Kutki root (125 mg) 
  • Ginger rhizome (75 mg) 
  • Grape seed extract (75 mg) 
  • Non-GMO, Vegan
  • Price: $$

What We Like:

    • N-acetyl cysteine 
    • Milk thistle
    • Alpha lipoic acid
    • Made in the USA
    • Good Manufacturing Practices

Room To Improve:

    • Unspecified return policy
    • Vitamin E

Final Thoughts

Liver Support from Parker Naturals contains many of our recommended ingredients, including milk thistle, ALA, and NAC.

Their formula also contains vitamin C, selenium, and turmeric, which may also support liver detoxification and whole body health

While Liver Support boasts a commendable variety of ingredients, the dosages for key ingredients are below our recommended levels, which may prevent this product from being as effective as others on our list. 

But at just under $37 for a two month supply, it takes the cake for the lowest price point.

Product Specs

  • 120 capsules (60 servings) 
  • Vitamin C (120 mg)
  • Choline (50 mg)
  • Selenium (100 mcg)
  • N-acetyl cysteine (400 mg) 
  • Milk thistle extract (350 mg) 
  • Artichoke leaf extract (100 mg)
  • Turmeric (50 mg)
  • Dandelion root extract (50 mg) 
  • Burdock root extract (40 mg)
  • Yellow Dock (25 mg)
  • Alpha lipoic acid (20 mg)
  • Non-GMO, Gluten Free, Dairy Free, Soy Free, Peanut Free, Shellfish Free, Vegan
  • Price: $

What We Like:

    • N-acetyl cysteine 
    • Milk thistle
    • Good Manufacturing Practices

Room To Improve:

    • No ALA
    • No vitamin E
    • 60-day return policy

Final Thoughts

Etta Vita’s NAC supplement is endorsed by former NFL quarterback Donovan McNabb and includes a few of our recommended ingredients.

While it doesn't contain ingredients like ALA and vitamin E, it contains a whopping 600 mg of NAC, which offers potential liver health benefits. Also, the formula doesn't have ALA and vitamin E, this may prevent the product from being as effective as others on our list.

Etta Vita’s liver supplement is also non-GMO, vegan, and third-party tested to ensure purity and consistency. Etta Vita offers a 60 day money-back guarantee.

Product Specs

  • 60 capsules per bottle (30 servings)
  • N-acetyl cysteine (600 mg)
  • Milk thistle (100 mg)
  • Molybdenum (50 mcg)
  • Selenium (25 mcg)
  • Quercetin (50 mg)
  • Non-GMO, Vegan, Soy Free, Gluten Free, Gelatin Free 
  • Price: $$

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Citations

  1. Cieslak, Kasia P., et al. "Liver Function Declines with Increased Age." HPB (Oxford) 18.8 (2016): 691-696. PMC4972366, doi:10.1016/j.hpb.2016.05.011.
  2. Metwaly, Ahmed M., et al. "Traditional Ancient Egyptian Medicine: A Review." Saudi Journal of Biological Sciences 28.10 (2021): 5823-5832. PMC8459052, doi:10.1016/j.sjbs.2021.06.044.
  3. Mokhtari, Vida, et al. "A Review on Various Uses of N-Acetyl Cysteine." Cell Journal 19.1 (2017): 11-17. PMC5241507, doi:10.22074/cellj.2016.4872.
  4. Molani-Gol, Roghayeh, et al. "Effects of Curcumin/Turmeric Supplementation on the Liver Enzymes, Lipid Profiles, Glycemic Index, and Anthropometric Indices in Non-alcoholic Fatty Liver Patients: An Umbrella Meta-Analysis." Phytotherapy Research, Online ahead of print, 2023 Nov 2., doi:10.1002/ptr.8051.
  5. Salehi, Bahare, et al. "Insights on the Use of α-Lipoic Acid for Therapeutic Purposes." Biomolecules 9.8 (2019): 356. PMC6723188, doi:10.3390/biom9080356.
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