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5 Brilliant Liver Detox Supplements

Learn how to tackle fatigue, bloating, & brain fog with a quality daily liver cleanse.

  • Written by: Brilliant Staff
  • Fact Checked by: Ellen Landes, MS, RDN, CPT
liver supplement products
The liver performs more than 500 daily tasks to keep you healthy. It cleanses your body of toxins, aids in digestion, absorbs nutrients, and produces energy.

So, it’s no wonder that when your liver is overworked, you experience a broad range of unpleasant symptoms like fatigue, bloating, brain fog, and fluctuations in metabolism.

Liver detox supplements can offer vital protection against these side effects — one reason they have taken social media by a storm.

Despite what influencers say, detoxes aren’t a new fad – liver cleansing dates all the way back to about 2000 BC.

But not all liver detox supplements are effective.

Many manufacturers use shoddy ingredients, improper dosages, or unnecessary additives. As you can imagine, the result lacks the health benefits you deserve.

We compiled months of research to show you what to look for, what to avoid, and how a liver detox supplement can improve energy levels, protect the liver, smooth digestion, and revitalize your health.

Key Benefits of Liver Detox Supplements

  • Liver Protection

  • Healthy Metabolism

  • Long-Lasting Energy

  • Smoother Digestion

  • Mental Clarity

Many ingredients used for centuries are still around today, and milk thistle remains a staple in detox formulas.

This powerful medicinal plant is considered an effective “liver tonic.”

And preliminary scientific research suggests that milk thistle seeds may have properties that help strengthen the liver, improve digestion, and aid in the detoxification process.
milk thistle flower
Newer ingredients, like N-Acetyl Cysteine, or NAC, have also garnered attention. Research suggests NAC not only promotes liver health, but can positively influence mood and the immune system.  

A quality liver supplement uses a blend of science-backed ingredients like those mentioned above.

Although, a long list of ingredients doesn’t always mean you’re getting a superior product. There are plenty of supplements with unnecessary add-ons and fillers — often as a way to inflate the asking price or to make up for low doses of key ingredients. 

So, what should you look for in your supplement? Our advice? Keep it simple.  

Here's our shortlist of key ingredients to look for in your liver supplement. 

Step 1

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Step 2

Tellus facilisis donec blandit massa nibh nunc. Ipsum maecenas lobortis turpis amet volutpat sed. Sit lectus velit ac rutrum. Amet suspendisse est suspendisse dignissim euismod amet lorem amet cursus. Massa turpis vitae porttitor et.

Step 3

Tellus facilisis donec blandit massa nibh nunc. Ipsum maecenas lobortis turpis amet volutpat sed. Sit lectus velit ac rutrum. Amet suspendisse est suspendisse dignissim euismod amet lorem amet cursus. Massa turpis vitae porttitor et.

Key Ingredients

Milk Thistle

Milk thistle is a potent herbal remedy that can help reduce occasional oxidative stress, supporting your liver as your body’s filter to cleanse you of toxins. Its properties may also aid in metabolizing hormones.

N-Acetyl Cysteine

NAC helps protect the liver by reducing oxidative stress and aids in removing toxins from your body. 

Alpha Lipoic Acid

Alpha Lipoic Acid, or ALA, is recognized as an antioxidant that may assist in nutrient absorption and energy metabolism. Its role in liver health, particularly in detoxification, is an area of ongoing research.

Vitamin E

Tocotrienols are a very potent form of vitamin E, or as we like to call them, supercharged vitamin E. This powerhouse ingredient can work to help cleanse your liver of toxins. 

Watch out for

Unnecessary Fillers

Even when a liver health supplement contains some great ingredients, it’s also important to look out for the “other” ingredients contained in their formula. 

These additional ingredients could include allergens, and dietary restricted ingredients such as animal derived ingredients, preservatives, or other additives. 

Frequently Asked Questions

What are the toxins the liver cleanses from my body?

Pollutants, air quality, and the food you eat are toxins you’re exposed to regularly. These toxins need to be detoxified and processed in the liver before reaching the rest of your body. 

Your liver works around the clock to make sure these  toxins are cleansed. If they aren’t filtered properly, it can affect your energy levels, digestion, mental health, and focus.

Why is the liver so important?

The liver is the cleanser and filter of the bloodstream and is of vital importance. It protects our bodies from toxins, absorbs nutrients, and sends them to different organs.

What makes alpha lipoic acid such a powerful antioxidant?

Alpha-lipoic acid (ALA) is unique in being both water and fat-soluble, which facilitates its action in various environments within the body. It has been scientifically shown to enhance the effectiveness of other antioxidants, contributing to its role in antioxidant defense systems.
Now that you know what to look for and avoid in your liver health supplement, it’s time to shop. 

Check out our Brilliant recommendations below, including LiverMD® from our in-house brand, 1MD Nutrition™ and LiverWell™ from Live Conscious®. LiverMD® is formulated by board-certified gastroenterologist, Dr. David Kahana. 

2024’s Must-Have Liver Detox Supplements

What We Like:

    • Clinically-studied milk thistle
    • N-acetyl cysteine
    • Alpha lipoic acid
    • Clinically-studied Vitamin E
    • Doctor-formulated
    • Good Manufacturing Practices
    • Made in the USA with global ingredients
    • 90-day return policy

Room To Improve:

    • Available only online

Final Thoughts

LiverMD is from our very own brand, 1MD Nutrition, and is formulated by board-certified gastroenterologist, Dr. David Kahana. 

LiverMD includes clinically-studied ingredients in its award-winning liver detox formula. Its patented vitamin E extract, TocoGaia, and patented milk thistle extract, Siliphos®, is added for its potential benefit of nutrient absorption and improving liver strength. 

Our formula is also vegan, non-GMO, and manufactured in a GMP-certified facility to ensure batch-to-batch purity and consistency.

If for any reason you are not satisfied with LiverMD, we offer a 100% satisfaction, 90-day money-back guarantee.

Product Specs

  • 60 capsules per bottle (30 servings) 
  • TocoGaia vitamin E extract (3.5 mg) 
  • Siliphos® milk thistle extract (160 mg)
  • N-acetyl cysteine (500 mg)
  • Alpha lipoic acid (100 mg)
  • Zinc citrate (15 mg)
  • Selenium amino acid chelate (200 mcg)
  • Gluten Free, Dairy Free, Peanut Free, Wheat Free, Shellfish Free, Non-GMO
  • Price: $$

What We Like:

    • Clinically studied milk thistle
    • N-acetyl cysteine
    • Vitamin E
    • Alpha lipoic acid
    • Zinc
    • Good Manufacturing Practices
    • 365-day return policy

Room To Improve:

    • Available exclusively online

Final Thoughts

LiverWell is another liver health supplement from our very own brand, Live Conscious. 

While not doctor-formulated and has a slightly lower dose of milk thistle, it still offers the same potent ingredients found in LiverMD, including 800 mg of NAC, patented milk thistle (Siliphos®), zinc, selenium, and alpha lipoic acid — all of which help detoxify the liver and fortify the immune system.

This product is manufactured in GMP-compliant facilities to ensure safety and purity in every bottle. 

All Live Conscious products are backed by a 365-day return policy, zero questions asked.

Product Specs

  • 60 capsules per bottle (30 servings) 
  • Siliphos® milk thistle extract (80 mg)
  • N-acetyl cysteine (800 mg)
  • Alpha lipoic acid (100 mg)
  • Zinc citrate (15 mg)
  • Selenium amino acid chelate (200 mcg)
  • Non-GMO, Gluten Free, Dairy Free, Soy Free, Peanut Free, Shellfish Free, Vegan
  • Price: $

What We Like:

    • Vitamin E
    • Milk thistle
    • Alpha lipoic acid
    • Doctor-formulated
    • Good Manufacturing Practices 
    • Made in the USA with global ingredients
    • Lifetime return policy

Room To Improve:

    • No NAC

Final Thoughts

OmniBiotic’s Liver Reboot contains powerful key ingredients like vitamin E, milk thistle, and alpha lipoic acid to support liver health. 

It also contains black chokeberry extract and a 300 mg blend consisting of ingredients like dandelion root, ginger, and grapeseed, which may also help support healthy liver function. 

While their formula does not use NAC or a clinically studied form of milk thistle, it contains a higher dose of ALA to support nutrient absorption. 

Liver Reboot is also non-GMO, vegan, made in the USA with globally sourced ingredients, and backed by a stellar lifetime money-back guarantee.

Product Specs

  • 60 capsules (30 servings) 
  • Vitamin E (10 mg)
  • Vitamin C (30 mg)
  • Zinc (10 mg)
  • Milk thistle (500 mg) 
  • Artichoke leaf (150 mg)
  • Schisandra fruit powder (150 mg)
  • Alpha lipoic acid (125 mg)
  • Dandelion root (125 mg) 
  • Kutki root (125 mg) 
  • Ginger rhizome (75 mg) 
  • Grape seed extract (75 mg) 
  • Non-GMO, Vegan
  • Price: $$

What We Like:

    • N-acetyl cysteine 
    • Milk thistle
    • Alpha lipoic acid
    • Made in the USA
    • Good Manufacturing Practices

Room To Improve:

    • Unspecified return policy
    • Vitamin E

Final Thoughts

Liver Support from Parker Naturals contains many of our recommended ingredients, including milk thistle, ALA, and NAC.

Their formula also contains vitamin C, selenium, and turmeric, which may also support liver detoxification and whole body health. 

While Liver Support boasts a commendable variety of ingredients, the dosages for key ingredients are below our recommended levels, which may prevent this product from being as effective as others on our list. 

But at just under $37 for a two month supply, it takes the cake for the lowest price point.

Product Specs

  • 120 capsules (60 servings) 
  • Vitamin C (120 mg)
  • Choline (50 mg)
  • Selenium (100 mcg)
  • N-acetyl cysteine (400 mg) 
  • Milk thistle extract (350 mg) 
  • Artichoke leaf extract (100 mg)
  • Turmeric (50 mg)
  • Dandelion root extract (50 mg) 
  • Burdock root extract (40 mg)
  • Yellow Dock (25 mg)
  • Alpha lipoic acid (20 mg)
  • Non-GMO, Gluten Free, Dairy Free, Soy Free, Peanut Free, Shellfish Free, Vegan
  • Price: $

What We Like:

    • N-acetyl cysteine 
    • Milk thistle
    • Good Manufacturing Practices

Room To Improve:

    • No ALA
    • No vitamin E
    • 60-day return policy

Final Thoughts

Etta Vita’s NAC supplement is endorsed by former NFL quarterback Donovan McNabb and includes a few of our recommended ingredients.

While it doesn't contain ingredients like ALA and vitamin E, it contains a whopping 600 mg of NAC, which offers potential liver health benefits. Also, the formula doesn't have ALA and vitamin E, this may prevent the product from being as effective as others on our list.

Etta Vita’s liver supplement is also non-GMO, vegan, and third-party tested to ensure purity and consistency. Etta Vita offers a 60 day money-back guarantee.

Product Specs

  • 60 capsules per bottle (30 servings)
  • N-acetyl cysteine (600 mg)
  • Milk thistle (100 mg)
  • Molybdenum (50 mcg)
  • Selenium (25 mcg)
  • Quercetin (50 mg)
  • Non-GMO, Vegan, Soy Free, Gluten Free, Gelatin Free 
  • Price: $$

What is lorum ipsum?

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What is lorum ipsum?

Tellus facilisis donec blandit massa nibh nunc. Ipsum maecenas lobortis turpis amet volutpat sed. Sit lectus velit ac rutrum. Amet suspendisse est suspendisse dignissim euismod amet lorem amet cursus. Massa turpis vitae porttitor et.

What is lorum ipsum?

Tellus facilisis donec blandit massa nibh nunc. Ipsum maecenas lobortis turpis amet volutpat sed. Sit lectus velit ac rutrum. Amet suspendisse est suspendisse dignissim euismod amet lorem amet cursus. Massa turpis vitae porttitor et.

What is lorum ipsum?

Tellus facilisis donec blandit massa nibh nunc. Ipsum maecenas lobortis turpis amet volutpat sed. Sit lectus velit ac rutrum. Amet suspendisse est suspendisse dignissim euismod amet lorem amet cursus. Massa turpis vitae porttitor et.

Citations

  1. Cieslak, Kasia P., et al. "Liver Function Declines with Increased Age." HPB (Oxford) 18.8 (2016): 691-696. PMC4972366, doi:10.1016/j.hpb.2016.05.011.
  2. Metwaly, Ahmed M., et al. "Traditional Ancient Egyptian Medicine: A Review." Saudi Journal of Biological Sciences 28.10 (2021): 5823-5832. PMC8459052, doi:10.1016/j.sjbs.2021.06.044.
  3. Mokhtari, Vida, et al. "A Review on Various Uses of N-Acetyl Cysteine." Cell Journal 19.1 (2017): 11-17. PMC5241507, doi:10.22074/cellj.2016.4872.
  4. Molani-Gol, Roghayeh, et al. "Effects of Curcumin/Turmeric Supplementation on the Liver Enzymes, Lipid Profiles, Glycemic Index, and Anthropometric Indices in Non-alcoholic Fatty Liver Patients: An Umbrella Meta-Analysis." Phytotherapy Research, Online ahead of print, 2023 Nov 2., doi:10.1002/ptr.8051.
  5. Salehi, Bahare, et al. "Insights on the Use of α-Lipoic Acid for Therapeutic Purposes." Biomolecules 9.8 (2019): 356. PMC6723188, doi:10.3390/biom9080356.

The Brilliant Process

How We Choose Products

Like you, we’re picky about products — and serious about quality. 

Whether we’re featuring an award-winning product from one of our five beauty and wellness brands — or somebody else’s — a Brilliant recommendation doesn’t see the light of day until it has been medically reviewed by our Fact Checkers for accuracy and has fulfilled our Brilliant Criteria. 

At Brilliant, although we often feature products that we sell, we’re not afraid to highlight and celebrate other brands who are doing things right.

Brilliant Criteria

We take great care in handpicking high-quality products to feature on Brilliant. Here’s how we choose them:
  • High-Quality Ingredients: We dig deep into the latest research and look for products that contain comprehensive ingredients for optimal impact.
  • Pure, Holistic Formulas: We prioritize products that contain clean, wholesome ingredients. A product should only contain what it needs and nothing else—period.
  • Brand Credibility: Each product on our list is produced by a company with trusted credibility. We've also verified that each brand adheres to labeling requirements set forth under current Good Manufacturing Practices (cGMP).
  • Value: We evaluate products based on industry averages and price per serving or application. We also consider quantity and return policy.

Why Trust Us?

As veteran leaders in the wellness space with an award-winning brand portfolio of 100+ health and beauty products, we are committed to honesty and transparency, providing thoughtful insights into the benefits and limitations of the information and products we evaluate — including our own. Every Brilliant Buying Guide is thoroughly vetted for medical accuracy by our Fact Checkers prior to publication. 

With our discerning selection process, you can feel confident that the products we recommend meet the highest benchmarks of quality, transparency, and efficacy. If we wouldn’t use a product ourselves, it’s not Brilliant. 
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